One of the areas that I believe will cause a significant shift in the architecture of both hardware and software is the advent of storage class memory. As memristors (or competing technologies) enter devices, we’ll see new applications of computing that are just not possible today.
When I saw this article about A magnetic memory with one bit per molecule, I found it exciting, since this structure was much smaller than other approaches. This technique though uses a scanning electron microscopeto activate the effect, it could be quite a while before we see this in a production device (if ever). On the other hand, the demonstration is an example of the variety of techniques being tried to create these very small and stable storage units.